个人简介

吕扬勇，博士，教授，博士生导师，河南省优秀青年基金获得者，河南省生物物理学会理事，长期从事真菌毒素合成调控和代谢调控方面的研究工作。主持国家自然科学基金面上项目、国家自然科学基金青年基金项目、河南省优秀青年基金项目等科研项目。获得河南省科学技术进步奖1项、教育厅科技成果奖1项、教育厅优秀科技论文一等奖1项；河南工业大学课程思政设计大奖赛和教学大奖赛二等奖各1项。以第一/通讯作者在Environmental Microbiology /Journal of Hazardous Materials/ Food Control等学术期刊发表论文40余篇，获国家专利2项，参编著作2部。

主持/参与项目

•河南省自然科学基金优秀青年基金项目：Afper1介导GPI锚定蛋白脂质重塑调控黄曲霉毒素合成机理研究 (222300420037)

•国家自然科学基金面上项目：2-羟基异丁酰化修饰及其调控黄曲霉毒素合成机理研究 (31972176)

•国家自然科学基金面上项目：多组学关联下热带假丝酵母耐受糠醛元器件的挖掘及耐性机制研究（21978070）

•国家自然科学基金青年基金项目：LaeA调控黄曲霉毒素合成的蛋白组学研究 ( 31501575)

•河南省教育厅自然科学项目科学技术研究重点项目基础研究计划：菌丝发育因子调控黄曲霉毒素合成机理研究

•河南工业大学“省属高校基本科研业务费专项资金”项目：黄曲霉毒素合成调控机理研究

•NSFC-河南联合基金重点项目：小麦玉米发酵生产酒精过程中微生物制剂降解真菌毒素的机制研究

第一/通讯作者学术论文

[1] Liang L, Wang X, Lan H, Wei S, Lei Y, Zhang S, Zhai H, Hu Y, Lv Y*. Comprehensive analysis of aflatoxin B1 biosynthesis in Aspergillus flavus via transcriptome-wide m6A methylome response to cycloleucine. Journal of Hazardous Materials, 2024, 461:132677.

[2] Liang L, Wang X, Wei S, Lei Y, Zhang S, Zhai H, Hu Yuansen, Lv, Y*. m6A methyltransferase AflIme4 orchestrates mycelial growth, development and aflatoxin B1 biosynthesis in Aspergillus flavus. Microbiological Research, 2024,283:127710.

[3] Lv Y^*, Wang J, Yang H, Li N, Farzaneh M, Wei S, Zhai H, Zhang S, Hu Y^*. Lysine 2-hydroxyisobutyrylation orchestrates cell development and aflatoxin biosynthesis in Aspergillus flavus. Environmental Microbiology, 2022, 24(9):4356-4368.Wang J^#,

[4] Lv Y^*, Yang H, Wang J, Wei S, Zhai H, Zhang S, Hu Y^*. Afper1 contributes to cell development and aflatoxin biosynthesis in Aspergillus flavus. International Journal of Food Microbiology, 2022, 377:109828.

[5] Wang J^#, Liang L^# (co-first authors), Wei, S, Zhang, S, Hu Y, Lv Y^*. Histone 2-hydroxyisobutyryltransferase encoded by Afngg1 is involved in pathogenicity and aflatoxin biosynthesis in Aspergillus flavus. Toxins, 2022, 15(1):7.

[6] Liang L, Yang H, Wei S, Zhang S, Chen L, Hu Y, Lv Y^*. Putative C2H2 transcription factor AflZKS3 regulates aflatoxin and pathogenicity in Aspergillus flavus. Toxins 2022, 14(12):883.

[7] Xin Y, Zhang W, Lei Y, Wei S, Zhang S, Li N; Hu Y, Lv Y*. Antifungal mechanism of p-anisaldehyde against Aspergillus flavus based on transcriptome analysis, LWT- Food Science and Technology, 2024, 195: 115844.

[8] Liang L, Xie A, Yang H, Li N, Ma P, Wei S, Zhang S, Lv Y^*, Hu, Y. Quantitative acetylome analysis of soft wheat seeds during artificial ageing. Foods, 2022, 11:3611.

[9] Tian P^#, Lv Y^# (co-first authors), Wei S, Zhang S, Li N, Hu Y^*. Antifungal properties of recombinant Puroindoline B protein against aflatoxigenic Aspergillus flavus. LWT-Food Science and Technology, 2021, 144:111130.

[10] Zhang W^#, Lv Y^# (co-first authors), Lv A, Wei S, Zhang S, Li C, Hu Y^*. Sub3 inhibits Aspergillus flavus growth by disrupting mitochondrial energy metabolism, and has potential biocontrol during peanut storage. Journal of the Science of Food and Agriculture, 2021, 101(2):486-496.

[11] Zhang W^#, Lv Y^# (co-first authors), Yang H, Wei S, Zhang S, Li N, Hu Y^*. Sub3 Inhibits mycelia growth and aflatoxin production of Aspergillus flavus. Food Biophysics, 2022, 17(2):248-259.

[12] Lv A^#, Lv Y^# (co-first authors), Tian P, Wei S, Zhang S, Hu Y^*. The antifungal activity of puroindoline A protein and its biocontrol potential for inhibiting Aspergillus flavus infection in peanut and corn. LWT-Food Science and Technology, 2020, 134:110184.

[13] Lv A, Li C, Tian P, Yuan W, Zhang S, Lv Y^*, Hu Y^*. Expression and purification of recombinant puroindoline A protein in Escherichia coli and its antifungal effect against Aspergillus flavus. Applied Microbiology and Biotechnology, 2019, 103:9515-9527.

[14] Lv Y^*, Lv A, Zhai H, Zhang S, Li L, Cai J, Hu, Y^*. Insight into the global regulation of laeA in Aspergillus flavus based on proteomic profiling. International Journal of Food Microbiology, 2018, 284:11-21.

[15] Tian P, Lv Y, Lv A, Yuan W, Zhang S, Li N, Hu, Y^*. Antifungal effects of fusion puroindoline B on the surface and intracellular environment of Aspergillus flavus. Probiotics and Antimicrobial Proteins, 2021, 13(1):249-260.

[16] Wang B^#, Lv Y^# (co-first authors), Li X, Lin Y, Deng H, Pan, L^*. Profiling of secondary metabolite gene clusters regulated by LaeA in Aspergillus niger FGSC A1279 based on genome sequencing and transcriptome analysis. Research in Microbiology, 2018, 169(2):67-77.

专利/获奖

(1) 吕扬勇(1/1), 河南省教育厅优秀科技论文一等奖, 河南省教育厅, 2020.

(2) 张帅兵, 吕扬勇, 胡元森, 蔡静平, 粮仓储粮霉菌活动监测系统V1.0, 2020SR1247261, 原始取得, 2018-9-20 (软件著作权).

(3) 翟焕趁, 张帅兵, 吕扬勇, 蔡静平, 朱冰洁, 一种粮食变质快速检测方法及其检测器, 2020-9-15, 中国, CN201810617173.6.

(4) 吕扬勇(12/15), 储粮中虫霉危害精准防控关键技术创新与应用, 河南省人民政府, 科技进步一等奖, 2024.

(5) 吕扬勇(8/14), 储粮中霉变虫害精准防控关键技术与装备创新及应用, 河南省教育厅, 2024.