宇光海

作者:时间:2017-06-17点击数:

基本信息
姓名: 宇光海                      
性别:
民族:
学历: 博士
职称: 副教授
职务:
个人简介
     宇光海,男,1983.01, 副教授,硕士研究生导师。2006年毕业于河北工业大学,2011年于天津大学获得博士学位。2011年7月任教于河南工业大学生物工程学院工作。主讲《制药工艺学》、《专业英语B》、《科技英语》等课程,主要从事微生物药学方向研究,主持国家自然科学基金项目1项,主持河南省教育厅高校重点科研项目1项,校基金2项,作为项目骨干成员参与7项国家自然科学基金和省部级项目,发表科研论文20余篇,其中SCI收录10余篇。荣获2016、2017、2018届毕业生“我心目中最优秀的老师”,2018届本科毕业设计(论文)优秀指导教师等光荣称号。

主要研究领域:

(1)微生物药用活性次级代谢产物资源开发与利用;

(2)抗生素生物合成转录调控机制研究;

(3)微生物药物的代谢工程育种;

(4)合成生物学/细胞工厂在微生物药学中的应用研究:

微生物药用活性次级代谢产物相关基因线路设计与研发

高效底盘细胞开发

代表性学术论文:

(1) G. Yu*, M. Hui, R. Li, Enhancement of Daptomycin Production by the Method of Combining Ribosome Engineering and Genome Shuffling in Streptomyces roseosporus, Applied Biochemistry and Microbiology, 2018, Vol. 54, No. 6, pp. 611–615

(2) Guanghai Yu*, Guoying Wang, Optimization of the Biosynthesis Conditions of Daptomycin by the Biostatistical Methodology, Interdiscip Sci Comput Life Sci (2017) 9:80–87

(3Guanghai Yu*, Yuansen Hu , Ming Hui, Genome Shuffling of Streptomyces roseosporus for Improving Daptomycin Production, Appl Biochem Biotechnol (2014) 172:2661–2669

(4) Guanghai Yu*, Improvement of daptomycin yield by overexpression of ATP-binding cassette (ABC) transport proteins genes of daptomycin gene cluster, Applied Mechanics and Materials Vols. 295-298 (2013) pp 164-168

(5) Yu G, Jia X, Wen J, Lu W, Wang G, Caiyin Q, et al. Strain improvement of Streptomyces roseosporusfor daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kineticmodeling. Appl Biochem Biotechnol. 2011;163:729-43.

(6) Yu G, Hu Y, Hui M, Chen L, Wang L, Liu N, et al. Genome shuffling of Streptomyces roseosporus forimproving daptomycin production. Appl Biochem Biotechnol. 2014;172:2661-9.

(7) Yu G, Jia X, Wen J, Wang G, Chen Y. Enhancement of daptomycin production in Streptomycesroseosporus LC-51 by manipulation of cofactors concentration in the fermentation culture. WorldJournal of Microbiology and Biotechnology. 2011;27:1859-68.

(8) Huang D, Jia X, Wen J, Wang G, Yu G, Caiyin Q, et al. Metabolic flux analysis and principal nodesidentification for daptomycin production improvement by Streptomyces roseosporus. Appl Biochem Biotechnol. 2011;165:1725-39.

(9) Huang D, Wen J, Wang G, Yu G, Jia X, Chen Y. In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement. Appl Microbiol Biotechnol. 2012;94:637-49.

(10) Shuai-Bing Zhang *Huan-Chen ZhaiLe WangGuang-Hai Yu. Expression, purification and characterization of a feruloyl esterase A from Aspergillus flavusProtein Expression and Purification2013.11.01921):36~40

 

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